In this issue, you'll hear how Twitter plans to become the leader in instant news - and transform itself into a sustainable business. You'll learn how IBM has found a way to turn its mathematicians' innovations into a new source of revenue. You'll hear how a biotechnology company from California has headed to the land of sugar in an effort to change the world for the better. And you'll learn how the old mechanism for funding the commercialization of new technologies is in big trouble.